The compound is designed to treat synaptopathies, a group of over 100 brain diseases characterized by synaptic loss and dysfunction.
This randomised, double-blind, placebo-controlled study will assess the safety, tolerability, pharmacokinetic and pharmacodynamic profile of single ascending and multiple ascending doses of RDN-929 in healthy volunteers ranging from 18 to 80 years old.
Inhibition of the CoREST complex targeted by RDN-929 is expected to reactivate neuronal gene expression, strengthen synaptic function and promote creation of new synapses while minimizing adverse effects.
RDN-929 preclinical data show pro-synaptic effects and suggest a safety profile suitable for long-term dosing as a therapeutic for neurodegenerative and neuropsychiatric diseases.
Rodin is also sponsoring an ongoing, non-therapeutic clinical trial to assess the performance of a new PET ligand that enables measurement of synaptic density in the living brain.
Results from this PET study and the newly launched Phase 1 trial will help guide Rodin's planned clinical trials of RDN-929 in patients with Alzheimer's disease, Parkinson's disease, frontotemporal dementia and other synaptopathies.
Rodin's lead compound is a potent and selective inhibitor of the CoREST complex. In preclinical studies, RDN-929 has demonstrated strong pro-synaptic pharmacological effects at multiple levels, including increase in the synaptic protein SV2A; significant, dose-dependent increase in dendritic spine morphology; and greater strength of synaptic function.
Rodin Therapeutics is discovering and developing first-in-class therapeutics for synaptopathies by applying novel chemical strategies to target specific HDAC complexes and upregulate key neuronal genes.
The company's targeted approach to strengthening synaptic integrity, backed by a robust translational strategy, has potential across multiple diseases, such as Alzheimer's disease, Parkinson's disease, frontotemporal dementia and schizophrenia, all of which are characterised by impaired neuronal and synaptic function.
GSK releases decade-long data on Shingrix efficacy
GSK announces positive EAGLE-1 results for gepotidacin in gonorrhoea treatment
Boehringer Ingelheim reports strong growth in 2023 and accelerates late-stage pipeline
Charles River Laboratories launches AMAP to reduce animal testing reliance
PureTech completes enrollment in Phase 2b ELEVATE IPF trial for LYT-100
Cybin secures additional US patent for CYB003 breakthrough therapy programme
UroGen's UGN-103 IND accepted by FDA for bladder cancer treatment
Biophytis reinforces obesity IP with new patent application
MaaT Pharma reveals positive 18-month data for MaaT013 in GI-aGvHD
Fusion Antibodies plc secures contract for OptiPhage library development
Innate Pharma advances Sanofi-developed NK cell engager to Phase 2 for blood cancer patients