Under the terms of the agreement for the study phase, ITM has partnered with Nordic Nanovector to support its clinical development.
At the same time, both parties signed a commercial agreement for the supply of EndolucinBeta post Marketing Approval of Betalutin.
Additional terms of the agreement are not disclosed.
EndolucinBeta, radiolabeled to anti-CD37 murine antibody lilotomab, is an active component of Betalutin, a next generation radioimmuno conjugate currently under clinical development in patients who suffer from Non-Hodgkin Lymphoma. Betalutin is a drug candidate with an excellent profile.
As well as leveraging an alternative therapeutic target (anti-CD37 antigen) in recurrent lymphoma patients who have relapsed following anti-CD20-based therapy, it has shown durable responses in heavily pre-treated NHL patients after a one-time administration, combined with a predictable and manageable toxicity, an important feature for elderly NHL patients who may not be suited to chemotherapy.
EndolucinBeta, a radiopharmaceutical precursor, is used in Targeted Radionuclide Therapy in the field of Precision Oncology and has marketing authorization in the EU.
Radiolabeled to disease-specific targeting molecules like antibodies or peptides, the tumor tissue is precisely destroyed by cytotoxic doses of ionizing radiation.
ITM has developed a unique methodology to produce a particularly highly pure form of Lutetium-177. No-carrier-added Lutetium-177 contains no metastable Lutetium-177m, therefore there is no need for cost intensive clinical waste management.
This is especially important in countries with a release limit of Lutetium-177m into public sewage systems.
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