Therapy Areas: Inflammatory Diseases
Cytonus Develops New Cell-Based Technology to Advance the Fight against Cancer and Inflammatory Diseases
6 February 2019 - - US-based biotechnology company Cytonus Therapeutics Inc. has developed Cargocytes a first-of-its-kind, controllable, cell-based platform technology for delivery of biologics, the company said.

Cargocytes are engineered allogenic cell lines that can carry a variety of payloads like small molecule compounds, gene editing therapies, therapeutic RNAs, and powerful biologics such as immune modulating cytokines, antibodies and oncolytic viruses.

Adoptive Cellular Therapies, such as Tumor Infiltrating Lymphocytes and T cells expressing Chimeric Antigen Receptors, are currently being tested and used to treat blood cancers, but do not work well on solid tumors.

They are also hindered by the need for a specific antigen target, long development times, adverse patient reactions, rapid degradation and a complex manufacturing process.

Cytonus Therapeutics Inc. is a spinout biotechnology company based on work done by founder and CSO Richard Klemke, Ph.D., professor of pathology at University of California San Diego School of Medicine.

Each year, more than 44,000 people in the US die from Pancreatic Cancer and 55,000 new cases are diagnosed. Most survive just five to six months after diagnosis because less than 10 % are diagnosed early enough where a surgical removal can be curative.

Despite some amazing scientific advancements in medicine, no one has been able to move the needle on the survival rates for Pancreatic Cancer in the past 40 years.

As a platform technology, Cargocyte has many therapeutic applications and will be commercialised through a blend of internal and partnered programmes.

Cytonus Therapeutics is a biopharmaceutical company developing a next-generation Adoptive Cellular Transport platform called Cargocytes.

The San Diego-based company's proprietary Cargocyte platform are cellular-engineered transporters of a multiplicity of therapeutic payloads to tissue in a selective, controllable and potent off-the-shelf cellular therapy for the potential treatment of several disease across multiple therapeutic areas.

Cytonus' initial focus is to advance Cargocyte candidates for the treatment of rare and difficult to treat cancers and inflammatory diseases.
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